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"Weight loss was associated with greater high-sensitivity CRP reduction in both treatment groups," said study presenter Jorge Plutzky, MD, director of Preventive Cardiology at Brigham and Women's Hospital, Boston, Massachusetts, but "with increased high-sensitivity CRP reductions in those receiving semaglutide." The drug also "significantly reduced high-sensitivity CRP early," he said, "prior to major weight loss and in those who did not lose significant amounts of weight." The reductions reached approximately 12% at 4 weeks and around 20% at 8 weeks, when the weight loss "was still quite modest," at 2% and 3% of body weight, respectively

However, Lyrica also carries with it some significant risks, including potential for abuse

Hormonal Changes : Levels of hormones such as leptin (which suppresses hunger) may decrease, while ghrelin (which stimulates appetite) may increase, leading to heightened feelings of hunger

Kastenberg D, Bertiger G, Brogadir S