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Caradonna, L., Amati, L., Magrone, T., Pellegrino, N., Jirillo, E., & Cacavvo, D
In each case, the FDA recommended against putting the peptide on the bulks list for compounders
Factors that affect TLS risk include tumor type (particularly hematologic malignancies), specific tumor characteristics (eg, bulky tumor, high cellular proliferation rate), and baseline creatinine (Wilson 2012)
Make sure patients understand exactly what off-label use means, what risks and benefits there are, and what the alternatives look like
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