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Human Evidence and Safety Human Studies: Only two very small pilot studies in humans exist (one for bladder pain, one for knee pain, each with fewer than 20 participants)7

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Moreover, we excluded patients and controls who suffered from neurodegenerative and neuroinflammatory disorders, such as chronic fatigue syndrome [54], Parkinsons or Alzheimers disease, multiple sclerosis, stroke, or systemic (auto)immune diseases such as diabetes mellitus, psoriasis, rheumatoid arthritis, inflammatory bowel disease and scleroderma, and liver and renal disease

In humans, ipamorelin does not have any recognized therapeutic uses