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FIGURE 14 The available structural data on the GLP-1GLP-1R system reveal that GLP-1 occupies the deep transmembrane pocket of the GLP-1R and establishes several intermolecular interactions with crucial residues on the N-terminus, ECL2, TM1, TM2, TM5, TM6, and TM7 of GLP-1R (Figure 14), which are also sustained over the duration of MD simulations
Dilute to volume with water and mix well to obtain the reference solution
Further comparative biochemical and pharmacological investigations are necessary before asserting that DHK-Cu merits the same recognition as its more established equivalents [2]
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