The age-related decline in the ability to synthesize GSH results in not only lower basal levels of GSH, but also a decreased adaptive response to CS
What GHK-Cu adds to the formulation: Gene expression modulation across hundreds of genes including collagen genes (Type I, III), tissue inhibitors of metalloproteinases, anti-inflammatory mediators Collagen synthesis stimulation, specifically Type I and Type III collagen the structural proteins of skin, connective tissue, and many other tissues Anti-inflammatory signaling through investigated effects on TNF-, IL-6, and NF-B pathways Copper-peptide chemistry effects including cofactor activity for skin-relevant enzymes Skin-research and hair-research applications (the GHK-Cu literature in these areas is substantial) For the GHK-Cu deep-dive, see Copper Peptides Explained
Glutathione is generally well-tolerated but may interact with certain medications or worsen symptoms in G6PD deficiency and some autoimmune conditions
It may feel most valuable for people who: If you are still deciding what outcomes are realistic, this article is a strong expectation-setter: does IV vitamin therapy really work