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This effect may be due either to inhibition of carbamyl phosphate synthase (CPS) I by -oxidation metabolites (CPS I is the first mitochondrial enzymatic step of the urea cycle) or to decreased synthesis of N -acetyl glutamic acid (NAGA) from acetyl-CoA and glutamate by NAGA synthetase (NAGA is an important cofactor of CPS I)

Syahrir M, Andayani YD, Norman D, Maksudin ES, Muharramah PF, Kgs MR,

Beverages and foods high in added sugars tend to rapidly spike blood sugar levels, often resulting in a short burst of energy followed by a steep drop in blood sugar (sugar crash) and fatigue

Magnetic Resonance Imaging