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Oral routes are preferred only when local GI action is the goal, when the molecule is engineered for oral stability, or when the peptidomimetic structure resists digestion

Al bloquear el sitio activo de la enzima de forma permeable a membrana, 5-Amino-1MQ reduce la produccin de 1-MNA y preserva la nicotinamida disponible, lo que en modelos experimentales se asocia con restauracin de los niveles intracelulares de NAD+ y SAM

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The increase of L-carnitine in plasma via oral administration, even up to and exceeding 2 mg, is limited, since L-carnitine has a very poor absorption and bioavailability, a very high renal clearance, and active uptake into tissues