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IGF-1 LR3 Research Applications The most established application of IGF-1 LR3 is as a growth factor supplement in serum-free mammalian cell culture, where Morris and Schmid (Biotechnology Progress, 2000) compared LongR3 against insulin in CHO lines expressing recombinant proteins, and where it is widely used as an insulin replacement at much lower concentrations

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This dramatic rise reflects updated clinical guidelines from the American Diabetes Association (ADA), which now recommend GLP-1 receptor agonists as first-line therapy for many patients