While citicoline is generally well tolerated and side effects are rare, sensitive users who experience GI discomfort cant practically reduce the dose below 500mg to test their tolerance.79 Additionally, since citicoline has a low elemental yield of 21%, youd have to take about 3g of it to reach the AI for an adult male (550mg of choline)
This work was supported by the National Institutes of Health under award numbers 2R01HL115189, P30DK04056, UE5DK137285, and U24 DK132733, and by the National Clinician Scholars Program at the Duke Clinical and Translational Science Institute
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Subcutaneous B12 shots tend to be less painful because the needle is not inserted deeply