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That said, the bigger picture matters

Among non-human primates (NHPs), the highest GLP-1 immunoreactivity is present in the hypothalamus, the area postrema, the NTS, and the dorsal vagal nucleus (51)

For context on what these results look like in practice, tirzepatide before and after results and male-specific tirzepatide transformations show real outcomes across different dose levels

Contraindications Tirzepatide, whether compounded or brand-name, should not be used by individuals with a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, severe gastroparesis or gastrointestinal disease, or during pregnancy