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It is also worth being explicit about what documented means here, because it is the load-bearing word for a YMYL page

Thus, lower levels of these metabolites in the starved urchin group would impair nucleotide synthesis, potentially leading to increased reliance on salvage pathways to maintain nucleotide pools

Congruently, the loss of KAT6A results in a shift in the expression of HOX genes (body segment identity), and the reduction in the expression of DLX genes (jaw and palate development) and TBX genes (heart development), among other affected genes (Voss et al, 2009, 2012

Erondu, N., et al., Diabetic Ketoacidosis and Related Events in the Canagliflozin Type 2 Diabetes Clinical Program