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The energy provided by B12 can also reduce the fatigue-driven eating that often undermines caloric restriction

Dose adjustment: If high-dose supplements cause symptoms, consider splitting the dose throughout the day or discussing a lower-strength preparation with your healthcare provider

Pernicious anaemia is caused by a deficiency in vitamin B12, due to atrophic gastritis, an autoimmune condition where the immune system destroys self, in this case the parietal cells of the stomach

Clinical trials conducted in the early 2000s showed modest results, and the compound failed to demonstrate sufficient efficacy to support regulatory approval as a weight-loss medicine