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J Neurosci Res 79:240247 Bogaert YE, Sheu KF, Hof PR, Brown AM, Blass JP, Rosenthal RE, Fiskum G (2000) Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation

This suggests that the levels of deoxyhemoglobin at the membrane surface exceed those in the cytosol

Another promising property of Madecassoside is that it seems to inhibit UV-induced melanin synthesis (test formula with 0.05% MA, used twice a day on 23 volunteers for 8 weeks), making it a great active for hyperpigmentation-prone skin