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Indeed central GLP-1 production appears essential, since peripheral GLP-1 is assumed to not be able to cross the blood-brain barrier (BBB)
These medications should be used with caution in people with severe gastrointestinal disease, including severe gastroparesis
The research, which analyzed data from nearly 775,000 adults, examined the association of mental health care utilization for comorbid depression and anxiety among patients with type 2 diabetes who were prescribed GLP-1s, compared with similar patients who were prescribed another class of diabetes medication called dipeptidyl peptidase-4 inhibitors (DPP-4is)
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