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This multi-step blockade of the oxidative stress - inflammation - tissue damage pathway, resulting in a reduction in renal tubular injury scores from 3.5 to 1.2 in a mouse IRI model in a mouse IRI model [64]

As a result, primary coenzyme Q 10 deficiency is a clinically heterogeneous disorder that includes five major phenotypes: (i) severe infantile multi-systemic disease, (ii) encephalomyopathy, (iii) cerebellar ataxia, (iv) isolated myopathy, and (v) nephrotic syndrome