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doi:10.1200/JCO.2017.77.4414 Uhelski ACR, Blackford AL, Sheng JY

Activity that may fit within FDA rules may still expose sellers to patent-infringement liability, attorneys said

Primary sites: Abdomen (avoiding 2 inches around the navel) Outer thighs Back of upper arms Upper buttocks Rotation pattern example: Day 1: Left abdomen Day 2: Right abdomen Day 3: Left thigh Day 4: Right thigh Day 5: Left arm Day 6: Right arm Day 7: Return to left abdomen Keep at least one inch between injection sites in the same general area

Over half reduction in wrinkle volume represents change that users and observers both notice