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While these results were statistically significant, they represent modest weight loss, particularly when compared to appetite-suppressing medications that typically produce more dramatic short-term results

The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes

Individuals with prior use of oral antidiabetic drugs or GLP-1 receptor agonists, a history of bariatric surgery, or conditions associated with unintentional weight loss (including malignancy or chronic infection) were excluded