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Two-hit vascular hypothesis of AD Blood vessel damage is thought to be the initial insult through which bloodbrain barrier dysfunction and/or diminished brain perfusion lead directly to amyloid- (A)-independent secondary neuronal injury (first hit) and A accumulation (second hit) in the brain owing to faulty A clearance and increased antibody production

doi:10.1590/1516-3180.2015.01382111

A 2026 UK review of the ~one-third of UK adults with insomnia symptoms, the glymphatic waste-clearance and amyloid link, the synaptic homeostasis hypothesis, why CBT-i and daridorexant (NICE TA922) come first, the BDNF / HGF-c-Met case, the vivid-dreams mismatch and why fixing sleep, not a peptide, comes first Read the full review Occupational & Stress Neuroscience 17 June 2026 Dihexa for Burnout Brain Fog: Chronic Work Stress, Cortisol, Cognition & the 2026 UK Review Im so burned out I cant think straight. In 2024/25 the HSE recorded a record 964,000 UK workers with work-related stress, depression or anxiety 22.1 million working days lost and the Mental Health UK Burnout Report 2026 found 91% had faced high pressure in the past year

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