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Nutrition and activity modifications become more critical during this windowincreasing protein intake to 25-30% of daily calories and maintaining consistent resistance exercise help counteract appetite rebound
In addition, tirzepatide affects certain chemicals in the brain which in turn decreases appetite, increases energy expenditure, and prevents ectopic fat deposition (abnormal fat accumulation in body parts that normally contains small amounts of fat)
Its effects, when present, tend to be modest and build over weeks not overnight
Moreover, rats treated with 1% neohesperidin dihydrochalcone for 1 month showed reduced amygdala neuroinflammation via suppression of cAMP/PKA pathway activity, restoration of cortical 5-HT, DA, and NE levels, and reversal of anxiety- and depression-like behaviors (Jiang et al., 2023)
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