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It must be taken on an empty stomach with minimal water (no more than 4 ounces), which creates a unique hydration challenge
It was showed that NP4 treatment leaded to an increase in pro-inflammatory M1-type macrophages and a decrease in anti-inflammatory M2-type macrophages in mouse tumor tissues, with the proportion of M1 to M2 macrophages being 4.4 times higher compared to untreated mouse tumor tissues (Fig
Further targeted research is needed to determine whether these theoretical benefits have any meaningful impact on rheumatoid arthritis disease activity
Mar 29 2023;380:e072003
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