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According to the MHRA/EMC SmPC, these include: Nausea (very common) Vomiting (very common) Diarrhoea (very common) Abdominal pain (common) Constipation (common) Dyspepsia/indigestion (common) Belching/eructation (common) These effects are typically dose-dependent and most pronounced during treatment initiation or dose escalation
Acylation chemistry targets lysine side chains, and with two lysines present the reaction would produce a mixture of positional isomers
Lilly has announced its intention to file a BLA, but that should not be confused with final FDA approval or a public FDA licensing decision
The AFM image described the particles within spherical to semi-spherical in shape
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
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