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2011), decrease aggregation of platelets (An et al
Retatrutide also produced a dysesthesia signal (8.820.9% at Phase 3 doses) the same new side effect now appearing with high-dose semaglutide, and its emergence in two separate next-generation drugs is a pattern worth watching
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Pica behavior is a validated endpoint to assess the ability of a compound to induce nausea/malaise in non-vomiting species, as mouse, based on the monitoring of non-nutritive (kaolin) food intake, as an index of gastrointestinal discomfort 43,44
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