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However, semaglutide has comprehensively surpassed exenatide in every clinical dimension: weight loss efficacy (approximately 4-5 fold greater), glycemic control (superior in SUSTAIN 3 head-to-head), cardiovascular outcomes (proven superiority vs non-inferiority), dosing convenience (pre-filled pen without reconstitution), and formulation options (oral available)
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Up to 92% of patients on tirzepatide achieved the ADA-recommended A1C target of less than 7%, compared to 81% on semaglutide
[Abstract]2020 Oct;36(5):399-416
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