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Applied Microbiology and Biotechnology
The details of the PIONEER program, including study design and results, have been published and reviewed extensively, therefore only a brief overview is provided here [38, 39, 61, 62, 76,77,78,79,80,81,82]
The FeS-binding proteins mitoNEET (also known as CISD1) and NAF1 (also known as CISD2), which have been shown to participate in mitochondrial iron transport, inhibit ferroptosis by protecting mitochondria from lipid peroxidation in cancer cells and acute kidney injury [52, 53]
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