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W., Wang, J

5 There is increased aromatase, which produces estrogen, as well as decreased 17-hydroxysteroid dehydrogenase 2 (17-HSD2), which breaks down estradiol to estrone, a more inert form of estrogen

early-results posts skew positive and ongoing-experience posts are more critical

The results paved the way for liraglutide, branded as Saxenda, to be approved in the US as a once-a-day subcutaneous injection in December 2014 and in Europe in 2015 for the treatment of chronic weight management combined with a reduced calorie diet and increased physical exercise (Molteni, Chen)