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A Phase 2 study published in the New England Journal of Medicine in 2023 (Jastreboff et al.) reported substantial weight loss in participants with obesity
While some of the trials reported a decrease in appetite as a side effect, like the ADJUNCT trials (60), it should be noted that this is one of the main mechanisms of action of these drugs to achieve weight loss
GLP-1 agonists are a class of prescription medications that were developed to help people with type 2 diabetes manage blood sugar levels
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