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Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease

Metformin also reversed the palmitate-induced serine phosphorylation of IRS-1, thus attenuating ER stress to inhibit hepatocellular apoptosis resulting from lipotoxicity (30).However, it should be noted that a study by Geng et al

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