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Yet, they added that, "the FDA is unable to determine how, or if, other factors may have contributed to these adverse events, such as differences in ingredients and formulation between FDA-approved and compounded semaglutide products." They also noted there was variation in the data quality in the reports they have received, which came only from 503B compounding pharmacies

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Women with PCOS or postmenopausal metabolic changes may have particular theoretical interest in retatrutide, though no sex-specific or condition-specific trials have been published