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Published studies are mostly small case reports rather than randomized trials
The American biochemist Loren Pickart discovered it in 1973 when he observed that liver tissue from older patients exhibited improved protein synthesis in the presence of plasma from younger donors
After that, your dose may be increased by 0.5mg every 4 weeks up to 2 mg once weekly, depending on how you respond to the medication For weight purposes, its important to follow medical advice, but generally, dosages should not exceed the maintenance dose of 2 mg once weekly, as this is considered the upper limit for safe use
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