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although both shorter and longer linkers have been reported, it still seems empirical and optimization is required for each pair of ligase and target protein, since it is likely that optimal linker identity will vary for different proteins targeted
Disulfide-linked polymerdrug conjugates and nanocarriers engineered for GSH-triggered drug release have shown favorable safety and preliminary efficacy profiles, highlighting the feasibility of translating redox-responsive strategies into clinical practice [120]
[9] It is important to note that whilst Ozempic is licensed for diabetes management in the UK, a higher-dose formulation (Wegovy, also semaglutide) has been specifically approved for weight management in certain patient groups
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