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Ellis et al8 reported a case of melanoma (Breslow depth of 1mm) in a 23-year-old patient who consulted for an increase in size of a pigmented lesion on his leg after use of Melanotan I
The injection volume may differ with combination products, which can affect the feel of the injection and the size of the subcutaneous depot
Penetration remains the central challenge
The key finding was that plasma concentrations in patients taking 8 mg of retatrutide (approximately 182 nanomolar) exceeded the effective concentrations observed in the laboratory, suggesting these cardiac effects are clinically relevant at therapeutic doses
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