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Side effects like nausea or stomach upset may improve over time
In some clinical trials, patients who received Semaglutide GLP-1 lost an average of 14.9% of their body weight over 68 weeks and experienced a reduction in waist circumference and visceral adipose tissue
The SURMOUNT and SURPASS trials showed tirzepatide may produce greater weight loss than semaglutide at comparable doses
84 documented even more substantial reductions, with total hip BMD decreasing by 7.6% and 9.2% at one and two years postoperatively, indicating persistent bone loss
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