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Gene expression analysis showed upregulation of survival pathways (Egr1, Akt1, Kras, Src, Foxo, Srf, VEGFR2, NOS1, NOS3) and downregulation of inflammatory mediators (NOS2, NFB)
Animal research used roughly 2-10 mcg/kg body weight orally
A key supporting study was retracted due to data fabrication, and the related prodrug fosgonimeton saw adverse events in clinical trials
Side effects are uncommon and usually mild: Soreness or redness at the injection site Mild digestive upset Allergic reactions, which are rare Because a shot is an injection, it should always be given by a trained provider
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