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Mech Ageing Dev 2000;120:1419
In conjunction with exercise and dieting, individuals who take weekly Semaglutide injections tend to see quicker weight loss that patients who do not receive these injections
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Quick Answer: Tirzepatide dose increases are considered after at least four weeks at the current dose when HbA1c remains above target, weight loss plateaus despite lifestyle adherence, or the current dose is well-tolerated without achieving therapeutic goals
There are theoretical off-ramps, but none have been tested. Mellor can describe what a well-designed trial might look like: A step-down protocol using lower doses, a transition through oral semaglutide or tirzepatide and/or a bridge using total diet replacement with food reintroduction and behavioral retraining
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