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NASH is defined by evidence of hepatocyte injury (ballooning) and inflammation, with or without fibrosis, in a liver biopsy
Food and Drug Administration (FDA) approved Foundayo(TM) (orforglipron) for adults with obesity or who are overweight with weight-related medical problems
The distribution of estimated life-years free of new and recurrent CVD events gained with semaglutide was wide, reflecting variation in absolute benefit gained with semaglutide between patients, with those with higher baseline risk and who were younger at treatment initiation experiencing the greatest absolute benefit. Researchers collected data from the SUSTAIN 6 and PIONEER 6 randomized, double-blind, placebo-controlled trials, both of which evaluated the effects of semaglutide (Wegovy, Novo Nordisk) in people with type 2 diabetes at high risk for CVD
