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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23

Additionally, BMI reduction through GLP-1 RAs may lower the risk of perioperative venous thromboembolism (VTE), although it remains unclear whether these agents exert direct effects on coagulation pathways [104]

The evidence base is narrow but consistent: lipotropic injections combined with caloric deficit produce 1525% greater fat loss over 12 weeks compared to caloric deficit alone, according to a 2021 meta-analysis published in Obesity Reviews