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Cross-trial scans favor tirzepatide: semaglutide measured about 62:38 fat-to-lean loss versus roughly 75:25 for tirzepatide. The scan overstates muscle loss, however, because lean mass includes water and organs
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They are often studied in combination
doi: 10.1158/0008-5472.Can-05-1553 200 ChenHSunMZhaoGLiuJGaoWSiSet al
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