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Medical Research Fund of Xian Science and Technology Bureau (22YXYJ0073)

[75] [76] The exact mechanisms involved in the development of schizophrenia and depression are not entirely clear, but the bioactive folate, methyltetrahydrofolate (5-MTHF), a direct target of methyl donors such as S-adenosyl methionine (SAMe), recycles the inactive dihydrobiopterin (BH 2 ) into tetrahydrobiopterin (BH 4 ), the necessary cofactor in various steps of monoamine synthesis, including that of dopamine and serotonin

Activating these anabolic receptors leads to increases in protein synthesis and tissue growth