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Your GP or diabetes specialist should: Evaluate whether symptoms coincide with dose escalation (suggesting a possible connection to treatment) Review all concurrent medications for potential contributors Assess for alternative causes, particularly thyroid function and menopausal status in women Consider whether glycaemic control has changed significantly Review insulin or sulfonylurea doses if hypoglycaemia is suspected For women experiencing menopausal hot flushes, hormone replacement therapy (HRT) is generally considered first-line treatment where appropriate, in line with NICE guidance

But the fat-burning signal from endogenous GH release is indirect and relatively weak compared to the direct triple-receptor activation that Retatrutide provides

In seeking to identify existing drugs with anti-fibrotic potential that could be repurposed, incretin receptor agonists, namely the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, are emerging as candidates