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The dual use of the same medications for diabetes and weight loss introduces operational complexity that did not exist when these drugs were confined to a single indication
In the phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), participants receiving higher doses of retatrutide achieved mean weight reductions of up to 17.5% of body weight over 24 weeks, with greater losses reported at 48 weeks
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TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation
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