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Specifically, there must be executive coordination among levels of the following hormones and enzymes: Rise and fall in multiple forms of estrogen (endogenous estradiol, estrone, and estriol as well as environmental xenoestrogens and dietary phytoestrogens) and estrogen receptors Rise and fall in progesterone and progesterone receptors Rise and fall in follicle-stimulating and luteinizing hormones (FSH and LH) Cortisol and other stress hormones, which can affect overall hormone balance Aromatase, COMT (catechol-O-methyltransferase), and other key sex hormone-metabolizing enzymes

doi:10.3390/ph16030185

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