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The Case for Microdose GLP-1: Cost-Effective Starting Therapy Many new weight-loss patients assume they must jump to full-dose tirzepatide or semaglutide immediately
Inadequate fiber intake can cause or worsen constipation
The results, which appear March 18 in BMJ Medicine, show that the consequences of stopping GLP-1 drugs go beyond weight regain, extending to increased cardiovascular risk, and underscore the importance of continuous treatment for sustained heart protection
This effect was fully suppressed by the microglial inhibitor minocycline and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580, underscoring the essential role of microglial activation and the p38 MAPK pathway [72]
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