Several new drugs are being developed, aimed at specific molecules involved in the bone remodeling process, such as inhibitors of cathepsin K (an enzyme secreted from osteoclasts, necessary for the resorption process) and inhibitors of the Wnt/-catenin-pathway inhibitors sclerostin and dickkopf-1
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McKee, Ph.D., a 2004 BBRF Young Investigator, recruited 48 participants at the University of North Carolina, Chapel Hill, for their phase 2 trial (such trials are typically small and are geared to determine if there is strong reason to test a therapy in a larger populationtypically at much greater expense and effort)