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Besides eryptotic PS exposure- or immune-mediated clearance, there are also lysis-dependent clearance mechanisms
In the phase 3 study REDEFINE 1 (about 3417 adults with obesity without diabetes, 68 weeks), the cagrilintide + semaglutide combination produced a mean weight reduction of 20.4% , versus 11.5% for cagrilintide alone, 14.9% for semaglutide alone and 3.0% for placebo
Interestingly, TIMP-2 knock out mice show deficits in fear potentiated startle (65)
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