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When the metabolism of the antioxidant system in cells is disturbed, it causes an increase in the accumulation of Fe 2+ within the cell, which in turn mediate the Fenton reaction to produce hydroxyl (-OH) or alkoxy (R-O) free radicals with different peroxides (Su et al., 2019) which can peroxidize with unsaturated fatty acids on the cell membrane

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In proof-of-concept studies, NNMT inhibitors (NNMTis) have demonstrated promise as potential treatments for obesity and obesity-related metabolic comorbidities (e.g., T2D, fatty liver) 8,9,13

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