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As a dual-action peptide, it targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, enhancing its efficacy
The discovery or design of native (exenatide) or engineered GLP-1 analogues that escape DPP-4 degradation and have a prolonged half-life, as well as DPP-4 inhibitors, have markedly improved the therapeutic landscape of type 2 diabetes over the last 13 years
If nausea is severe and persistent, resources on semaglutide bloating , tirzepatide bloating , and general GLP-1 side effect management provide targeted strategies
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