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Yin Z, Albrecht J, Syversen T, Jiang H, Summar M, Rocha JBTda, Farina M, Aschner M (2009) Comparison of alterations in amino acids content in cultured astrocytes or neurons exposed to methylmercury separately or in co-culture

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The structural modifications extend plasma half-life from approximately 1020 minutes for native IGF-1 to approximately 2030 hours for IGF-1 LR3, producing a substantially different pharmacokinetic profile than the native molecule despite identical receptor pharmacology [1]