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To address this gap, this review explores four key areas: (1) the core mechanisms of mitochondrial metabolic reprogramming in CRC and its role in driving therapeutic resistance

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153 It should be considered that KD also presents some risks, as they are typically high in saturated fats and may lack a substantial amount of nutrients, specifically carbohydrates and dietary fiber, as well as micronutrients such as calcium, magnesium, potassium and vitamins A, B and B6