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Current opinion in investigational drugs (London, England : 2000)
Second, and more critically, the expansion of water as it freezes can create immense pressure inside the vial, potentially causing micro-fractures in the glass or compromising the seal of the rubber stopper
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Such reactions can range from responses with no clinical manifestations to irritating rashes to life-threatening conditions such as anaphylactic shock, which constricts breathing and impairs motor function
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