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10 In the DAPA-HF trial, among 4,700 patients with a significantly reduced mean LVEF (31% 6.7), most classified as New York Heart Association (NYHA) class II, dapagliflozin provided a 26% RR reduction in the primary composite outcome (CV death, HF hospitalisation and urgent visits for worsening HF), regardless of the presence or absence of type 2 diabetes (T2D), with a NNT of 21

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NADPH play a role in the synthesis of reduced glutathione and maintains cell redox state, whereas ribose 5-phosphate constitutes the sugar of purine and pyrimidine nucleotides (62)

By activating GLP-1 receptors, semaglutide promotes insulin secretion while simultaneously reducing glucagon secretion, leading to better control of blood sugar levels